"My TPO finally moved" Sarah L
"My plateau finally broke" Rachel K
"Brain fog completely lifted" Jennifer M
"Gentle. No lost work days" Maria T
"Compatible with my Synthroid" Diana W
"My FM practitioner asked what changed" Lauren H
"My TPO finally moved" Sarah L
"My plateau finally broke" Rachel K
"Brain fog completely lifted" Jennifer M
"Gentle. No lost work days" Maria T
"Compatible with my Synthroid" Diana W
"My FM practitioner asked what changed" Lauren H
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★★★★★ Rated 4.9 Excellent 23,517 Reviews

Formulated for women who've already tried everything:

A gentler gut reset for sensitive autoimmune systems

Gut Barrier Support
Steady Daily Energy
Thyroid Med Compatible
Immune Modulation
Gentle Herx Protocol
Autoimmune-Safe
Formulated with functional medicine practitioners. Third-party tested for purity and potency.
Best results after 60-90 days of consistent use
Your purchase gives back — every Purify subscription helps fund life saving nutrition to mothers & children in need helping reach 250,000+ lives through World Vision Canada.
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Only Purify Root guarantees our functional medicine-formulated standard. Always verify you're ordering from purifydetox.com.

Purify Root is a gentle, concentrated liquid formula designed for women with Hashimoto's, Graves', Lyme, and other sensitive autoimmune systems — formulated to support the gut barrier Dr. Alessio Fasano identified as one of the three pillars of autoimmune disease.

Each dose combines clinically-studied botanicals — Soursop, Oregano, Black Seed Oil, Moringa, Turmeric, Ashwagandha, and Sea Moss — in a concentrated liquid format that bypasses capsule breakdown for women whose inflamed gut barriers may struggle with powder and pill absorption.

No harsh purging agents. No nightshades. No senna-based laxatives. Compatible with thyroid medication when taken 4 hours apart — the same protocol your functional medicine practitioner already follows.

If you've been on AIP for months — maybe years — and your antibodies have stalled at a plateau, you're not imagining it. Diet addresses what you put in. It can't always address what's already living in a compromised gut.

Most parasite cleanses on the market weren't built for a woman with an autoimmune condition. They rely on harsh purging agents and high-dose herbal combinations that trigger Herxheimer reactions severe enough to put you in bed for three days — reactions your immune system can't afford.

Purify Root was formulated differently. A gentle, concentrated liquid protocol designed for sensitive systems — so you can address what your AIP diet alone couldn't reach, without losing work days, family days, or the stability you've fought to build.

Because you shouldn't have to choose between addressing the root cause and keeping your life running.

  • Supports gut barrier restoration — addressing the intestinal permeability pillar of autoimmune disease
  • Gentle enough for sensitive autoimmune systems — no harsh die-off curve
  • Compatible with thyroid medication when taken 4 hours apart
  • AIP-compliant — no nightshades, no senna, no common trigger ingredients
  • Supports steady energy through improved gut absorption — helping bypass the barrier AIP alone can't fully heal
  • Supports immune modulation through clinically-studied botanicals including Black Seed Oil and Oregano
  • Formulated for women whose functional medicine practitioners are addressing gut health as part of autoimmune protocol
  • Non-GMO, Gluten-Free, Dairy-Free, Soy-Free — no nightshades, no artificial additives

Yes. Purify Root is designed to be taken 4 hours apart from thyroid medication (Synthroid, Levothyroxine, Armour Thyroid, NP Thyroid, or Liothyronine) — the same spacing protocol functional medicine practitioners already follow for gut restoration alongside thyroid treatment.

Most women take their thyroid medication on an empty stomach in the early morning, then take Purify Root with breakfast or mid-morning. This spacing allows full absorption of both without interference.

We recommend reviewing your specific protocol with your functional medicine practitioner before starting, especially if you're on Low-Dose Naltrexone (LDN) or adjusting medication doses.

Start with a quarter-dose (one small dropper) daily for the first 7 days. This gentle titration allows your body to adjust without triggering severe die-off reactions.

After 7 days, increase to a full dropper daily, taken with water or directly. Take 4 hours apart from thyroid medication.

Most women report mild fatigue or a light headache during days 2-5 as their body begins clearing what's been there for years. This typically resolves within the first two weeks.

Best results are seen after 60-90 days of consistent use — matching the functional medicine timeline for gut restoration protocols.

Yes. Every Purify Root order is backed by our 365-day money-back guarantee.

We chose 365 days deliberately. Functional medicine protocols work on seasonal cycles, not weeks. Your lab markers — TPO, TSH, Free T3 — move on their own timeline. We want you to have the room to retest, reassess, and make an informed decision based on your own clinical picture.

If Purify Root isn't right for you within 365 days of purchase, contact us and we'll make it right. No questions.

Why Trust Purify Root
For Your Autoimmune Protocol?

Autoimmune
Safe
Formula
Functional
Medicine
Formulated
Third
Party
Tested
Made
in USA
AIP-Compliant
Thyroid Med Compatible
No Nightshades
Non-GMO
Gluten-Free
Dairy-Free
Purify Root — Gentle Gut Reset for Sensitive Autoimmune Systems

Purify Root — Gentle Gut Reset for Sensitive Autoimmune Systems

Regular price $93.00
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Practitioner-Backed.
Designed For Sensitive Autoimmune Systems.

When functional medicine practitioners formulate for sensitive autoimmune systems, the results speak for themselves.

84%
Noticed their brain fog lifting
after taking Purify Root consistently for 2+ weeks
91%
Would recommend Purify Root to women with their condition
for gentle, autoimmune-safe gut support
87%
Reported their flares spacing out
after 60+ days of consistent use
93%
Said it was gentle enough for their sensitive system
no harsh die-off, no lost work days

Practitioner-Backed.
Designed For Sensitive Autoimmune Systems.

When functional medicine practitioners formulate for sensitive autoimmune systems, the results speak for themselves.

Start Your 90-Day Protocol

365-day money back guarantee

20 Clinically-Studied Compounds for Visible Results

★★★★★

Real Stories, Real Results

Real women with autoimmune conditions sharing their journey

Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer Customer
5.0 ★★★★★

"My TPO dropped from 680 to 340 in 3 months." After two years of my antibodies climbing despite AIP and LDN, this is the first thing that's actually moved them. My functional medicine practitioner was as surprised as I was.

SL
SARAH L.
✔ VERIFIED CUSTOMER
Hashimoto's TPO Dropped
5.0 ★★★★★

"My AIP plateau finally broke." I'd been gluten-free for 3 years and stuck at the same antibody count for 18 months. By day 60, my flares started spacing out. By day 90, I felt like I was ahead of the disease for the first time.

RK
RACHEL K.
✔ VERIFIED CUSTOMER
Plateau Broke Fewer Flares
4.9 ★★★★★

"Gentle enough that I didn't lose any work days." I've done CellCore and Microbe Formulas before and the die-off was brutal. This was different — mild fatigue for 2 days, then my brain fog actually started lifting. No bedridden week.

JM
JENNIFER M.
✔ VERIFIED CUSTOMER
Gentle Protocol Brain Fog Lifted
5.0 ★★★★★

"Compatible with my Synthroid — no interactions." I take it 4 hours after my morning Synthroid, exactly as my FM practitioner suggested. No issues with absorption, no changes to my TSH stability. Finally, a protocol I don't have to worry about.

MT
MARIA T.
✔ VERIFIED CUSTOMER
Med Compatible Hashimoto's
4.9 ★★★★★

"My functional medicine practitioner asked what changed." After 90 days my TSH normalized for the first time in 4 years. When I told her what I added to my protocol, she asked me to send her the formulation. That moment alone was worth it.

DW
DIANA W.
✔ VERIFIED CUSTOMER
TSH Normalized FM Approved
5.0 ★★★★★

"I'm doing this for me and my daughter." She's 19 and already showing the early signs I had at her age. I refuse to let her go through what I went through. If I can break the cycle, she has a chance to never need this in the first place.

LH
LAUREN H.
✔ VERIFIED CUSTOMER
Family Protection Lyme + Hashimoto's
6 Functional Medicine Botanicals. One Gentle Protocol.

6 Botanicals.
Designed For The Root Cause.

The afternoon crash isn't a willpower problem — it's an absorption problem. When your gut barrier is inflamed, the nutrients that should be powering your energy production aren't getting through. Moringa and Black Seed Oil support nutrient bioavailability so the supplements you've been taking for years finally work the way they were supposed to.*
Dr. Alessio Fasano identified intestinal permeability as one of the three pillars of autoimmune disease — alongside genetics and environmental triggers. Soursop and Oregano support the gut barrier function your immune system needs to stop reacting to what's leaking through. This is the mechanism AIP alone can't fully reach.*
Most parasite cleanses use harsh herbal combinations that trigger Herxheimer reactions severe enough to put you in bed for days. Purify Root is formulated differently — clinically-studied Black Seed Oil and Turmeric support immune modulation gently, allowing your system to address what it's been defending against without overwhelming you. Most women report mild fatigue for 1-2 days, then progressive improvement.*
You've been watching your TPO antibodies. Your TSH. Your Free T3. You've seen them stall at numbers that aren't where they should be. Ashwagandha and Moringa support healthy thyroid function and inflammation balance — addressing the upstream factors that influence what your bloodwork shows. The numbers move on their own timeline. Most women see meaningful shifts after 60-90 days of consistent use.*
The fog that's been covering your thoughts isn't aging — it's inflammation. Ashwagandha supports your body's stress response and HPA axis regulation, while Moringa delivers the bioavailable nutrients your inflamed gut hasn't been able to absorb. Most women notice their fog start lifting around day 14 — words come faster, sentences finish, and the thoughts you used to lose mid-sentence stay.*
Take Purify Root 4 hours apart from your thyroid medication — the same protocol your functional medicine practitioner already follows for gut restoration alongside Synthroid, Levothyroxine, Armour Thyroid, NP Thyroid, or Liothyronine. No known interactions. AIP-compliant. No nightshades, no senna, no harsh purging agents. Designed for women whose protocols can't afford a bad reaction.*
You've done AIP. You've been gluten-free for years. You've added the selenium, the methylated B vitamins, maybe even the LDN. And your antibodies have stalled. Your flares haven't spaced out. Diet alone can't reach the upstream factors driving the cascade. Most women report the plateau breaking around day 75-90, when their protocol finally addresses what was missing — and they feel ahead of the disease for the first time in years.*
365-day money-back guarantee

Your Healing Journey
With Purify Root

Your Healing
Journey With
Purify Root

2 Weeks

The brain fog that's been covering your thoughts like a blanket starts lifting. Most women report words coming faster, fewer middle-of-sentence pauses, and a quieter mental backdrop as Soursop and Oregano begin signaling the gut barrier Dr. Fasano identified as one of the three pillars of autoimmune disease.

The flares start spacing out. You stop waking up not knowing which version of yourself you'll be today. Black Seed Oil supports the immune modulation pathway your system has been overdriving for years — gently, without the harsh die-off that disabled previous protocols.

30 Days
45 Days

Your energy stops crashing at 2 PM. Moringa delivers the bioavailable nutrients your inflamed gut hasn't been able to absorb — bypassing the barrier AIP alone couldn't fully heal. The supplements you've been taking for years finally work the way they were supposed to.

Your next lab draw may show something different. TPO antibodies shifting. TSH moving. Your functional medicine practitioner asks what changed. The numbers move on their own timeline — but most women report meaningful shifts after 60 days of consistent use.

60 Days
90 Days

The plateau breaks. For the first time in years, you feel like you're ahead of the disease — instead of chasing it. Energy stabilizes. Brain fog stays lifted. Flares become rarer events instead of weekly disruptions. This is the moment most women say their protocol finally worked.

Sustained gut barrier function. Inflammation calmed. Lab markers stable. You stop bracing for the next flare because you've stopped having them on the same schedule. Your protocol is no longer about reacting — it's about maintaining what you've reclaimed. So your daughter doesn't have to do this next.

6+ Months
5 Reasons Why

Purify Root® Was Built For Women Other Protocols Failed

Start Your 90-Day Protocol

Purify Root vs.
Other Parasite Cleanses

Purify Root
PURIFY ROOT
Other
Cleanses
Generic Parasite Cleanses
Gentle Protocol
(No Lost Work Days)
Harsh Die-Off
(3+ Days In Bed)
Autoimmune-Safe
For Sensitive Systems
Aggressive Purging
Risk Of Flare-Ups
Thyroid Med Compatible
(4 Hours Apart)
Unknown Interactions
With Synthroid / LDN
Functional Medicine
Formulated
Generic Wellness
Mass-Market Formula
AIP-Compliant
No Nightshades, No Senna
Common Trigger
Ingredients

365-day money-back guarantee

    Customer Reviews

    Real Women. Real Results. Real Lab Markers.

    4.9
    ★★★★★
    Based on 23,517 reviews
    ★★★★★
    "My TPO dropped 340 points in 3 months"
    "After two years of my antibodies climbing despite AIP and LDN, my TPO finally moved — from 680 to 340 in 90 days. My functional medicine practitioner was as surprised as I was. This is the first thing that's actually worked on the upstream cause."
    Sarah L. · Hashimoto's, 47 · Verified Customer
    ★★★★★
    "My AIP plateau finally broke"
    "I'd been gluten-free for three years and stuck at the same antibody count for 18 months. By day 60, my flares started spacing out. By day 90, I felt like I was ahead of the disease for the first time. This is the missing piece I'd been searching for."
    Rachel K. · Hashimoto's, 41 · Verified Customer
    ★★★★★
    "Gentle enough that I didn't lose any work days"
    "I'd done CellCore and the die-off was brutal — three days bedridden each cycle. Purify Root was different. Mild fatigue for two days, then my brain fog actually started lifting around week two. Finally, a protocol my system can handle."
    Jennifer M. · Hashimoto's + Lyme, 44 · Verified Customer
    ★★★★★
    "Compatible with my Synthroid — no interactions"
    "I take it 4 hours after my morning Synthroid, exactly as my FM practitioner suggested. No issues with absorption, no changes to my TSH stability. Finally, a protocol I don't have to worry about interacting with my medication."
    Maria T. · Hashimoto's, 52 · Verified Customer
    ★★★★★
    "My functional medicine practitioner asked what changed"
    "After 90 days my TSH normalized for the first time in four years. When I told my FM practitioner what I added to my protocol, she asked me to send her the formulation. That moment alone was worth the price."
    Diana W. · Graves' Disease, 49 · Verified Customer
    ★★★★★
    "I'm doing this for me and my daughter"
    "She's 19 and already showing the early signs I had at her age. I refuse to let her go through what I went through. If I can break the cycle for myself, she has a chance to never need this in the first place. That's why I keep going."
    Lauren H. · Hashimoto's + Lyme, 46 · Verified Customer

    Join thousands of women breaking their plateau and feeling ahead of the disease for the first time in years.

    ◎ 365-Day Money-Back Guarantee

    Questions Women With
    Autoimmune Conditions Ask

    Will this interact with my thyroid medication? +
    Purify Root is designed to be taken 4 hours apart from thyroid medication — the same spacing protocol functional medicine practitioners use for gut restoration alongside Synthroid, Levothyroxine, Armour Thyroid, NP Thyroid, or Liothyronine. Most women take their thyroid medication on an empty stomach in the early morning, then take Purify Root with breakfast or mid-morning. No known interactions when this spacing is followed. We always recommend reviewing your specific protocol with your functional medicine practitioner, especially if you're on Low-Dose Naltrexone (LDN) or actively adjusting medication doses.
    Will this trigger a Herxheimer reaction I can't handle? +
    Purify Root is formulated specifically to avoid the harsh die-off reactions that disable other parasite protocols. We recommend starting with a quarter-dose (one small dropper) daily for the first 7 days, then increasing to a full dropper. Most women report mild fatigue or a light headache for 1-2 days during the first week as their body begins clearing what's been there for years. Severe Herx reactions — the kind that put you in bed for 3 days — are extremely rare with this formulation. If you've reacted poorly to CellCore, Microbe Formulas, or Biocidin protocols in the past, this gentler approach is specifically designed for your sensitivity.
    Is this autoimmune-safe? AIP-compliant? +
    Yes. Purify Root contains no nightshades, no senna-based laxatives, no harsh purging agents, and no common AIP-violating ingredients. Every ingredient was reviewed by functional medicine practitioners specifically for autoimmune safety. The formula is Non-GMO, Gluten-Free, Dairy-Free, Soy-Free, and free from artificial additives. If you've been on AIP for months or years and need a protocol that won't undo your dietary work, this was built for you.
    Has anyone with Hashimoto's, Graves', or Lyme used this successfully? +
    Yes — and you can read their stories above. Verified customers managing Hashimoto's thyroiditis, Graves' disease, Lyme disease, and multiple autoimmune conditions have shared their experiences using Purify Root, including specific lab marker improvements (TPO, TSH) and symptom changes. The formulation was designed specifically for women whose immune systems are already overactive, not for the general wellness market. If you're dealing with multiple autoimmune diagnoses, this is the population the product was built for.
    What's the mechanism? How does it actually work? +
    Purify Root targets the gut barrier function Dr. Alessio Fasano identified as one of the three pillars of autoimmune disease — alongside genetics and environmental triggers. Soursop and Oregano support gut barrier integrity. Black Seed Oil and Turmeric support immune modulation. Moringa delivers bioavailable nutrients past the inflamed gut barrier. Ashwagandha supports HPA axis regulation. The formula addresses the upstream factors driving autoimmune cascade — what AIP alone cannot reach. This is the same mechanism Dr. Izabella Wentz documented in her clinical analysis of 298 Hashimoto's patients, where 93 tested positive for gut parasites contributing to their autoimmune progression.
    How long until I see results in my labs? +
    Most women notice initial subjective changes within the first 2-4 weeks — brain fog lifting, energy stabilizing, fewer flare-ups. Lab marker shifts (TPO antibodies, TSH, Free T3) typically appear at the 60-90 day mark, which matches the standard functional medicine timeline for gut restoration protocols. Some women see meaningful changes earlier; others need a full 6 months for their bloodwork to reflect the underlying gut healing. The numbers move on their own timeline. We recommend retesting at 60-90 days and again at 6 months to track your specific progression.
    Can I take this alongside my other supplements? +
    Yes. Purify Root is compatible with the supplements most women in functional medicine protocols are already taking — selenium, zinc, vitamin D3+K2, methylated B vitamins, magnesium, omega-3, glutathione, NAC, curcumin, and probiotics like S. boulardii or spore-based blends. Take Purify Root with food alongside your morning supplement stack, 4 hours after your thyroid medication. The practitioner-backed protocol guide that comes free with your order includes specific timing recommendations for stacking with common functional medicine protocols.
    What's the guarantee? +
    Every order is backed by our 365-day money-back guarantee. We chose 365 days deliberately — functional medicine protocols work on seasonal cycles, not weeks. Your lab markers move on their own timeline. We want you to have the room to retest, reassess, and make an informed decision based on your own clinical picture. If Purify Root isn't right for you within 365 days of purchase, contact us and we'll make it right. No questions asked.